Table 2

2×2 rANOVA models of outcome measures

Mean (SD)ProductTimeProduct×time interaction
Outcome measureCigarette smokingLittle cigar smokingF valuep ValueF valuep ValueF valuep Value
Plasma nicotine (ng/mL)0.90.33855.0<0.001*0.30.570
 Presmoking19.1 (10.3)18.1 (12.3)
 Postsmoking39.1 (19.8)35.3 (11.7)
COex (ppm)†<0.10.84925.3<0.001*0.10.731
 Presmoking29 (22)28 (18)
 Postsmoking35 (21)36 (19)
Product weight (g)21.4<0.001*1175.6<0.001*20.0<0.001*
 Presmoking1.08 (0.05)0.92 (0.02)
 Postsmoking0.41 (0.09)0.41 (0.13)
QSU factor 14.10.048*104.5<0.001*4.30.044*
 Presmoking26 (8)21 (7)
 Postsmoking12 (7)12 (7)
QSU factor 20.50.50245.6<0.001*1.30.265
 Presmoking18 (7)16 (7)
 Postsmoking10 (5)10 (6)
QSU total2.10.15481.4<0.001*2.90.095
 Presmoking45 (14)38 (14)
 Postsmoking21 (11)22 (13)
  • *Denotes significance at p<0.05.

  • †Log-transformed variable included in the rANOVA model.

  • COex, exhaled carbon monoxide; rANOVA, repeated measures analysis of variance.