Table 1

Compounds in mainstream aerosol of Marlboro HeatSticks compared with 3R4F reference cigarette

PMI product	Unit	PMI-58	IQOS HeatStick	3R4F	Change (%) with 3R4F on stick basis
1,2,3-Propanetriol, diacetate (diacetin)	µg/stick	No	1.23	0.381	↑ 223
1,2-Propanediol, 3-chloro	µg/stick	No	9.94	5.93	↑ 68
1,4-Dioxane, 2-ethyl-5-methyl-	µg/stick	No	0.055	0.0004	↑ 13 650
12,14-Labdadiene-7,8-diol, (8a,12E)	µg/stick	No	1.43	0.064	↑ 2134
1 hour-Indene, 2,3-dihydro-1,1,5,6-tetramethyl-	µg/stick	No	0.026	0.014	↑ 86
1-Hydroxy-2-butanone	µg/stick	No	0.947	0.465	↑ 104
1-Hydroxy-2-propanone(1,2-Propenediol)	µg/stick	No	162	96.8	↑ 67
2 (5H)-Furanone	µg/stick	No	5.32	1.99	↑ 167
2,3-Dihydro-5-hydroxy-6-methyl‐4 hour‐pyran‐4‐one	µg/stick	No	0.231	0.135	↑ 71
2,4-Dimethylcyclopent-4-ene-1,3-dione	µg/stick	No	0.333	0.193	↑ 73
2-Cyclopentene-1,4-dione	µg/stick	No	3.8	0.764	↑ 397
2-Formyl-1-methylpyrrole	µg/stick	No	0.128	0.064	↑ 100
2-Furancarboxaldehyde,5-methyl-	µg/stick	No	11.1	2.94	↑ 278
2-Furanmethanol	µg/stick	No	39.2	7	↑ 460
2-Furanmethanol, 5-methyl-	µg/stick	No	0.123	0.029	↑ 324
2 hour-Pyran-2-one,tetrahydro-5-hydroxy	µg/stick	No	4.45	3.11	↑ 43
2-Methylcyclobutane-1,3-dione	µg/stick	No	2.78	0.71	↑ 292
2-Propanone, 1-(acetyloxy)-	µg/stick	No	16.9	8.01	↑ 111
3 (2H)-Furanone, dihydro-2-methyl-	µg/stick	No	0.326	0.119	↑ 174
3-Methylvaleric acid	µg/stick	No	5.1	3.63	↑ 40
4(H)-Pyridine, N-acetyl-	µg/stick	No	0.296	0.112	↑ 164
5-Methylfurfural	µg/stick	No	0.995	0.632	↑ 57
Anhydro linalool oxide	µg/stick	No	0.457	0.291	↑ 57
Benzene, 1,2,3,4-tetramethyl-4-(1-methylethenyl)-	µg/stick	No	0.006	0.005	↑ 20
Benzenemethanol, 4-hydroxy-	µg/stick	No	0.011	0	↑
Benzoic acid, 2,5-dihydroxy-methyl	µg/stick	No	4.55	2.18	↑ 109
Butylated hydroxytoluene	µg/stick	No	0.132	0.007	↑ 1786
Butyrolactone	µg/stick	No	4.08	0.728	↑ 460
Cis-sesquisabinene hydrate	µg/stick	No	0.061	0	↑
Cyclohexane, 1,2-dioxo-	µg/stick	No	0.083	0.046	↑ 80
Cyclohexane-1,2-dione, 3-methyl-	µg/stick	No	0.101	0.073	↑ 38
Eicosane, 2-methyl-	µg/stick	No	0.05	0.014	↑ 257
Ergosterol	µg/stick	No	3.18	1.58	↑ 101
Ethyl 2,4-dioxohexanoate	µg/stick	No	6.73	3.57	↑ 89
Ethyl dodecanoate (ethyl laurate)	µg/stick	No	0.023	0	↑
Ethyl linoleate	µg/stick	No	0.135	0.008	↑ 1588
Ethyl linolenate	µg/stick	No	0.614	0.153	↑ 301
Furfural	µg/stick	No	31.1	25.9	↑ 20
Glycerol	mg/stick	No	5.02	2.08	↑ 141
Glycidol	µg/stick	No	5.71	1.76	↑ 224
Heneicosane, 2-methyl-	µg/stick	No	0.063	0.021	↑ 200
Hexadecanoic acid, ethyl ester	µg/stick	No	0.491	0.008	↑ 6038
Isolinderanolide	µg/stick	No	4.99	1.85	↑ 170
Isoquinoline, 3-methyl	µg/stick	No	6.29	4.99	↑ 26
Labdane-8,15-diol, (13S)	µg/stick	No	0.143	0.015	↑ 853
Lanost-8-en-3-ol, 24-methylene‐, (3beta)	µg/stick	No	6.3	1.61	↑ 291
Maltoxazine	µg/stick	No	0.077	0.038	↑ 103
Methyl furoate	µg/stick	No	0.147	0.029	↑ 407
Phenylacetaldehyde	µg/stick	No	1.41	0.529	↑ 167
p-Menthan-3-ol	µg/stick	No	0.786	0.322	↑ 144
Propylene glycol	µg/stick	No	175	23.7	↑ 638
Pyranone	µg/stick	No	6.54	5.07	↑ 29
Pyranone	µg/stick	No	9.26	5.84	↑ 59
Pyridoxin	µg/stick	No	0.699	0.526	↑ 33
Stearate, ethyl-	µg/stick	No	0.074	0.003	↑ 2367
Tar	mg/stick	No	19.4	25	↓ 22
Trans-4-hydroxymethyl-2-methyl-1,3-dioxolane	µg/stick	No	2.09	0.044	↑ 4650
1,3-Butadiene	µg/stick	Yes	0.21	89.2	↓ 99.8
1-Aminonaphthalene	ng/stick	Yes	0.043	20.9	↓ 99.8
2-Aminonaphthalene	ng/stick	Yes	0.022	17.5	↓ 99.9
3-Aminobiphenyl	ng/stick	Yes	0.007	4.6	↓ 99.8
4-Aminobiphenyl	ng/stick	Yes	0.009	3.21	↓ 99.7
Acetaldehyde	µg/stick	Yes	192	1602	↓ 88
Acetamide	µg/stick	Yes	2.96	13	↓ 77
Acetone	µg/stick	Yes	30.7	653	↓ 95
Acrolein	µg/stick	Yes	8.32	158	↓ 95
Acrylamide	µg/stick	Yes	1.58	4.5	↓ 65
Acrylonitrile	µg/stick	Yes	0.145	21.2	↓ 99.3
Ammonia	µg/stick	Yes	12.2	33.2	↓ 63
Arsenic	ng/stick	Yes	<0.36	<7.49	NA
Benz[a]anthracene	ng/stick	Yes	2.65	28.4	↓ 91
Benzene	µg/stick	Yes	0.45	77.3	↓ 99.4
Benzo[a]pyrene	ng/stick	Yes	0.736	13.3	↓ 94
Butyraldehyde	µg/stick	Yes	20.7	81.3	↓ 74
Cadmium	ng/stick	Yes	<0.28	89.2	↓ >99.7
Carbon monoxide	mg/stick	Yes	0.35	29.4	↓ 99
Catechol	µg/stick	Yes	14	84.1	↓ 83
Chromium	ng/stick	Yes	<11.0	<11.9	NA
Crotonaldehyde	µg/stick	Yes	<3.29	49.3	↓ >93
Dibenz[a,h] anthracene	ng/stick	Yes	<0.124	<0.689	NA
Ethylene oxide	µg/stick	Yes	<0.119	16	↓ >99.3
Formaldehyde	µg/stick	Yes	14.1	79.4	↓ 82
Hydrogen cyanide	µg/stick	Yes	<1.75	329	↓ >99.5
Hydroquinone	µg/stick	Yes	6.55	94.5	↓ 93
Isoprene	µg/stick	Yes	1.51	891	↓ 99.8
Lead	ng/stick	Yes	2.23	31.2	↓ 93
m-Cresol	µg/stick	Yes	0.042	4.24	↓ 99
Mercury	ng/stick	Yes	1.38	3.68	↓ 63
Methyl-ethyl-ketone	µg/stick	Yes	10.1	183	↓ 94
Nickel	ng/stick	Yes	<15.9	<12.9	NA
Nicotine	mg/stick	Yes	1.29	1.74	↓ 26
Nitric oxide	µg/stick	Yes	12.6	484	↓ 97
Nitro benzene	µg/stick	Yes	<0.011	<0.038	NA
Nitrogen oxides	µg/stick	Yes	14.2	538	↓ 97
N-nitrosoanabasine	ng/stick	Yes	2.35	29	↓ 92
N-nitrosoanatabine	ng/stick	Yes	14.7	254	↓ 94
NNK	ng/stick	Yes	7.8	244.7	↓ 97
NNN	ng/stick	Yes	10.1	271	↓ 96
o-Cresol	µg/stick	Yes	0.078	4.81	↓ 98
o-Toluidine	ng/stick	Yes	1.1	96.2	↓ 99
p-Cresol	µg/stick	Yes	0.071	9.6	↓ 99
Phenol	µg/stick	Yes	1.47	15.6	↓ 91
Propionaldehyde	µg/stick	Yes	10.8	109	↓ 90
Propylene oxide	ng/stick	Yes	142.3	896	↓ 84
Pyrene	ng/stick	Yes	8.2	79.2	↓ 90
Pyridine	µg/stick	Yes	6.58	30.9	↓ 79
Quinoline	µg/stick	Yes	<0.011	0.43	↓ >98
Resorcinol	µg/stick	Yes	<0.055	1.72	↓ >97
Selenium	ng/stick	Yes	1.27	<4.42	NA
Styrene	µg/stick	Yes	0.58	13.9	↓ 96
Toluene	µg/stick	Yes	1.42	129	↓ 99
Vinyl chloride	ng/stick	Yes	<0.657	93.4	↓ >99
Water	mg/stick	Yes	30.2	14.7	↑ 105

Notes: presented in table 1 of Addendum to FDA Briefing Document, January 24-25, 2018, Meeting of the Tobacco Products Scientific Advisory Committee; sata source: section 3.3.2 and section 6.1.1.3.4 of the Modified Risk Tobacco Product application (MRTPAs) and appendix A of an amendment to the MRTPAs submitted on 8 December 2017. Total particulate matter and nicotine-free dry particulate matter, two constituents on the PMI-58 list were not reported by PMI in this table.
↑, higher in IQOS; ↓, lower in IQOS.
PMI, Philip Morris International; PMI-58, PMI’s list of 58 constituents.