Table 1

Liver parameters in Sprague Dawley rats after 90 days of exposure

	Female			Male
	Sham	IQOS	3R4F	Sham	IQOS	3R4F
ALT levels (IU/L)	51.0±4.4	73.0±3.2,**	54.0±2.6	57.0±6.5	75.0±6.7*	68.0±5.8
Liver weight†	339.6±6.6	442.6±10.2*,**	386.7±15.1*	329.3±5.1	381.7±13.2**	373.0±7.9***
Hepatocellular vacuolisation	0.7±0.4	1.5±0.2*	1.2±0.3	1.4±0.3	0.8±0.4	1.8±0.8

Data are from Wong et al 1 and are presented as mean±SEM.
*P<0.05 relative to sham; **P<0.01 relative to sham; ***P<0.001 relative to sham; ****P<0.01 relative to 3R4F.
†Normalised to body weight and reported as ×10⁻⁴.
ALT, alanine aminotransferase.