Changes in pulmonary function testing from day 0 to day 90 in the US-based study (ZRHM-REXA-08-US)
| Clinical endpoint | Conventional cigarettes (n=30) | IQOS (n=47) | Smoking abstinence (n=9) | P values |
| FEV1 (% predicted) | −3.1 (−5.6 to –1.7) | −2.3 (−4.6 to –0.04) | −2.9 (−11.3 to 5.6) | 0.72 |
| FVC (% predicted) | −2.6 (−4.4 to 0.9) | −1.8 (−3.4 to –0.05) | −0.6 (−4.5 to 3.4) | 0.57 |
| FEV1/FVC | 0.01 (−0.004 to 0.02) | −0.004 (−0.02 to 0.01) | 0.04 (0.002 to 0.08) | 0.01 |
| MEF 25–75 (L/s) | −0.1 (−0.3 to 0.2) | −0.1 (−0.3 to 0.05) | 0.2 (−0.8 to 1.1) | 0.57 |
| DLCO (mL/min/mm Hg) | 0.2 (−1.0 to 1.3) | 0.2 (−0.8 to 1.2) | −1.5 (−5.1 to 2.2) | 0.40 |
| TLC (L) | −0.3 (−0.6 to 0.1) | −0.02 (−0.3 to 0.2) | −0.6 (2.0 to 0.7) | 0.15 |
DLCO, diffusion capacity of lung for carbon monoxide; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; MEF, mid expiratory flow; TLC, total lung capacity.