Table 1

Summary of preclinical pulmonary findings for I-Quit-Ordinary-Smoking (IQOS) compared with sham and 3R4F research cigarette groups

Lung weight (normalised to body weight)35.8 (1.4)40.3 (1.0)*50.6 (1.4)*†
BAL cell count‡ (×105/lung)22.9 (3.4)42.5 (7.1)*116.4 (13.4)*†
BAL inflammatory markers MIP-1β, MCP-3, MPO, PAI-1↑*↑*†
Respiratory epithelial hyperplasia and metaplasia↑*↑*†
  • Unless otherwise specified, results signify those from male rats at the highest nicotine exposure levels for each group.

  • *Significantly increased compared with sham.

  • †Significantly increased compared with IQOS.

  • ‡Female rats at targeted nicotine 23 µg/L.

  • BAL, bronchoalveolar lavage; MCP, monocyte chemoattractant protein; MIP, macrophage inflammatory protein; MPO, myeloperoxidase; PAI, plasminogen activator inhibitor.