Summary of preclinical pulmonary findings for I-Quit-Ordinary-Smoking (IQOS) compared with sham and 3R4F research cigarette groups
| Parameter | Sham (n=10) | IQOS (n=8–10) | 3R4F (n=9) |
| Lung weight (normalised to body weight) | 35.8 (1.4) | 40.3 (1.0)* | 50.6 (1.4)*† |
| BAL cell count‡ (×105/lung) | 22.9 (3.4) | 42.5 (7.1)* | 116.4 (13.4)*† |
| BAL inflammatory markers MIP-1β, MCP-3, MPO, PAI-1 | ↑* | ↑*† | |
| Respiratory epithelial hyperplasia and metaplasia | ↑* | ↑*† |
Unless otherwise specified, results signify those from male rats at the highest nicotine exposure levels for each group.
*Significantly increased compared with sham.
†Significantly increased compared with IQOS.
‡Female rats at targeted nicotine 23 µg/L.
BAL, bronchoalveolar lavage; MCP, monocyte chemoattractant protein; MIP, macrophage inflammatory protein; MPO, myeloperoxidase; PAI, plasminogen activator inhibitor.