Relative levels of HPHC in mainstream HnB aerosol compared with reference cigarette
| Schaller et al 25 2016 | Schaller et al 24 2016 | Jaccard et al 26 2017 | Auer et al
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2017 | Bekki et al
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2017 | Eaton et al 28 2018 | Forster et al
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2018 | Poynton et al 30 2017 | |||||
| Affiliation | PMI | PMI | PMI | University of Bern, Switzerland | National Institute of Public Health, Japan | BAT | BAT | BAT | ||||
| Tobacco stick | R. IQOS | R. IQOS | M. IQOS | R. IQOS | R. IQOS | R. IQOS | M. IQOS | R. glo | R. IQOS | R. glo | M. glo | R. iFuse |
| Reference cigarette | 3R4F | 3R4F | 3R4F | 3R4F | Lucky Strike Blue | 3R4F | 3R4F | 3R4F | 3R4F | 3R4F | 3R4F | 3R4F |
| Puffing regimen | HCI | HCI | HCI | HCI | ISO | HCI | HCI | HCI | HCI | HCI | HCI | HCI* |
| 1,3-Butadiene | <1% | <1% | <1% | <1% | – | – | – | <1% | <1% | <1% | <1% | <1% |
| 1-Aminonaphthalene | <1% | <1% | <1% | <1% | – | – | – | – | <1% | <1% | <1% | <1% |
| 2-Aminonaphthalene | <1% | <1% | <1% | <1% | – | – | – | – | <1% | <1% | <1% | 3% |
| 4-Aminobiphenyl | <1% | <2% | <2% | <1% | – | – | – | – | <1% | <1% | <1% | 3% |
| Acetaldehyde | 12% | 14% | 13% | 13% | 22% | – | – | 5% | 15% | 5% | 5% | <1% |
| Acrolein | 7% | 7% | 6% | 6% | 82% | – | – | 1% | 6% | 1% | 2% | 5% |
| Acrylonitrile | 1% | <1% | <1% | <1% | – | – | – | – | <1% | <1% | <1% | <1% |
| Ammonia | 38% | 36% | 35% | 36% | – | – | – | – | 33% | 12% | 15% | <50% |
| Benzene | <1% | <1% | <1% | <1% | – | – | – | <1% | <1% | <1% | <1% | <1% |
| Benzo[a]pyrene | 7% | 9% | 8% | 6% | 4%†/8%‡ | – | – | <3% | 5% | 2% | 3% | <7% |
| Carbon monoxide | 1% | 2% | 2% | 1% | – | 1% | 1% | <1% | 1% | <1% | <1% | 21% |
| Crotonaldehyde | <6% | 6% | 5% | <6% | 4% | – | – | 5% | 1% | 2% | <3% | |
| Formaldehyde | 11% | 10% | 8% | 9% | 74% | – | – | 6% | 11% | 6% | 7% | 13% |
| Isoprene | <1% | <1% | <1% | <1% | – | – | – | – | <1% | <1% | <1% | <1% |
| NNN | 5% | 6% | 4% | 4% | – | 6% | 8% | 9% | 4% | 9% | 7% | <1% |
| NNK | 3% | 3% | 2% | 3% | – | 5% | 5% | 2% | 4% | 2% | 2% | <1% |
| Toluene | 2% | 1% | 1% | 1% | – | – | – | – | 1% | <1% | <1% | 2% |
| Nicotine | 73% | 70% | 64% | 61% | 84% | 65% | 71% | – | 57% | 23% | 18% | 139% |
| Water | 203% | 231% | 188% | – | – | 328% | 350% | – | 168% | 80% | 71% | – |
| Glycerol | 203% | 191% | 163% | – | – | – | – | – | 182% | 129% | 101% | – |
| Total particulate matter | 122% | 98% | 89% | – | – | 119% | 135% | – | 104% | 56% | 54% | – |
| Tar/nicotine-free dry particulate matter | 79% | 33% | 40% | – | – | 39% | 53% | – | 75% | 46% | 48% | – |
*Puffing duration increased to 3 s, levels of HPHC for HnB product measured for 100 puffs.
†Originally reported proportions of HnB relative to polycyclic aromatic hydrocarbons in mainstream smoke of 50 commercial US cigarettes.
‡Proportions recalculated using mean values of polycyclic aromatic hydrocarbons in mainstream smoke of 50 commercial US cigarettes measured by ISO smoking regimen.15
BAT, British American Tobacco; HnB, heat-not-burn tobacco product; HPHC, harmful and potentially harmful compounds; ISO, International Organisation for Standardisation; M, menthol; NNK, nicotine-derived nitrosamine ketone; NNN, N-nitrosonornicotine; PMI, Philip Morris International; R, regular; –, not measured.