Table 4

Relative levels of HPHC in mainstream HnB aerosol compared with reference cigarette

Schaller et al 25 2016Schaller et al 24 2016Jaccard et al 26 2017Auer et al 21
2017
Bekki et al 23
2017
Eaton et al 28 2018Forster et al 36
2018
Poynton et al 30 2017
AffiliationPMIPMIPMIUniversity of Bern, SwitzerlandNational Institute of Public Health, JapanBATBATBAT
Tobacco stickR. IQOSR. IQOSM. IQOSR. IQOSR. IQOSR. IQOSM. IQOSR. gloR. IQOSR. gloM. gloR. iFuse
Reference cigarette3R4F3R4F3R4F3R4FLucky Strike Blue3R4F3R4F3R4F3R4F3R4F3R4F3R4F
Puffing regimenHCIHCIHCIHCIISOHCIHCIHCIHCIHCIHCIHCI*
 1,3-Butadiene<1%<1%<1%<1%<1%<1%<1%<1%<1%
 1-Aminonaphthalene<1%<1%<1%<1%<1%<1%<1%<1%
 2-Aminonaphthalene<1%<1%<1%<1%<1%<1%<1%3%
 4-Aminobiphenyl<1%<2%<2%<1%<1%<1%<1%3%
 Acetaldehyde12%14%13%13%22%5%15%5%5%<1%
 Acrolein7%7%6%6%82%1%6%1%2%5%
 Acrylonitrile1%<1%<1%<1%<1%<1%<1%<1%
 Ammonia38%36%35%36%33%12%15%<50%
 Benzene<1%<1%<1%<1%<1%<1%<1%<1%<1%
 Benzo[a]pyrene7%9%8%6%4%†/8%‡<3%5%2%3%<7%
 Carbon monoxide1%2%2%1%1%1%<1%1%<1%<1%21%
 Crotonaldehyde<6%6%5%<6%4%5%1%2%<3%
 Formaldehyde11%10%8%9%74%6%11%6%7%13%
 Isoprene<1%<1%<1%<1%<1%<1%<1%<1%
 NNN5%6%4%4%6%8%9%4%9%7%<1%
 NNK3%3%2%3%5%5%2%4%2%2%<1%
 Toluene2%1%1%1%1%<1%<1%2%
 Nicotine73%70%64%61%84%65%71%57%23%18%139%
 Water203%231%188%328%350%168%80%71%
 Glycerol203%191%163%182%129%101%
 Total particulate matter122%98%89%119%135%104%56%54%
 Tar/nicotine-free dry particulate matter79%33%40%39%53%75%46%48%
  • *Puffing duration increased to 3 s, levels of HPHC for HnB product measured for 100 puffs.

  • †Originally reported proportions of HnB relative to polycyclic aromatic hydrocarbons in mainstream smoke of 50 commercial US cigarettes.

  • ‡Proportions recalculated using mean values of polycyclic aromatic hydrocarbons in mainstream smoke of 50 commercial US cigarettes measured by ISO smoking regimen.15

  • BAT, British American Tobacco; HnB, heat-not-burn tobacco product; HPHC, harmful and potentially harmful compounds; ISO, International Organisation for Standardisation; M, menthol; NNK, nicotine-derived nitrosamine ketone; NNN, N-nitrosonornicotine; PMI, Philip Morris International; R, regular; –, not measured.