Initial Host: Biobehavioral scope
| Behavioural factors | Biological factors |
| Relapse | Flavour preference |
| Withdrawal | Biomarkers of exposure/harm |
| Co-occurring use of other tobacco products | Nicotine metabolism |
| Cue reactivity/craving | Health effects (short and long term) |
| Dependence | Health status (pre-exposure and post-exposure to tobacco products and their by-products) |
| Topography of tobacco product use, including patterns of use | Pregnancy status |
| Genetic factors |