Table 2

Studies reporting on nicotine delivery from a 5% strength JUULpod via a JUUL device using machine sampling

Study and flavours tested	Puff		Inter Puff Interval	# of puffs	Device	Nicotine			Marlboro Red filtered cigarette equivalents†
Study and flavours tested	Volume	Duration	Inter Puff Interval	# of puffs	Device	mg in the e-liquid per pod	µg per puff	If 200 puffs per pod*	Marlboro Red filtered cigarette equivalents†
Mallock 20202 Virginia tobacco	55 mL	3 s	30 s	20	Standard linear smoking machine designed for e-cigarettes	--	72 µg	14.4 mg	13
Talih 202034 Tobacco	67 mL	4 s	10 s	15	AUB Aerosol Lab Vaping Instrument	45.5 mg	87 µg	17.4 mg	16
Talih 20191 Tobacco	67 mL	4 s	10 s	15	AUB Aerosol Lab Vaping Instrument	48.0 mg	137 µg	27.4 mg	25
Goniewicz 201931 Unspecified flavour	70 mL	2 s	10 s	10	‘Smoking machine’	39.3 mg	83 µg	16.6 mg	15
Reilly 201935 Fruit medley, mint, tobacco, crème brulee	75 mL	2.5 s	30 s	10	Human Puff Profile Cigarette Smoking Machine (CH Technologies, NJ)	--	164 µg	32.8 mg	30
Erythropel 201915 Eight flavours‡	79 mL	2.8 s	30 s	20	Custom-built vaping machine, liquid nitrogen-chilled traps	--	114 µg	22.8 mg	21
Omaiye 201914 Eight flavours‡	100 mL	4.3 s	60 s	¾ of pod	Cole-Parmer Masterflex L/S peristaltic pump	42.6 mg	144 µg	28.8 mg	26

*The JUUL website FAQ has indicated that each JUULpod offers about 200 puffs.36
†Per FTC testing protocol, Marlboro Red filtered 100 mm hard pack cigarette delivers 1.1 mg nicotine per cigarette.46 A more recent study reported Marlboro Red filtered regular 79 mm cigarette delivers 1.04 mg nicotine.47 Used here is the 1.1 mg nicotine value for 100 mm Marlboro Red hard pack cigarettes. Values rounded.
‡Flavours tested: Crème Brulée, Fruit Medley, Mango, Cool Cucumber, Cool Mint, Classic Menthol, Classic Tobacco, Virginia Tobacco
FAQ, Frequently Asked Questions; FTC, Federal Trade Commission.