Table 1

Liquid composition of JUUL pods before and after the Food and Drug Administration flavour enforcement policy

Cool Mint 2017Classic Menthol 2017Cool Mint 2018Classic Menthol 2018Menthol 2018Menthol 2020
JUUL liquid composition
 Nicotine concentration (mg/mL)58.13*
(0.96)		58.14*
(0.38)		57.69*
(0.65)		60.14
(0.96)		60.14
(1.34)		64.09
(2.00)
 Free base nicotine (%)2.26
(0.26)		2.05
(0.31)		3.60
(0.41)		2.33
(0.20)		3.18
(0.29)		2.88
(0.06)
 PG/VG (%v/v)27/6327/6327/6327/6327/6326/64
 Menthol concentration (mg/mL)7.44†
(0.28)		7.54†
(0.12)		8.05†
(0.23)		7.39*
(0.34)		9.71†
(0.20)		11.96
(0.19)
% other compounds (semi-quantitative)
 3-Octanol0.23
(0.02)		ND0.41
(0.02)		NDNDND
 p-Mentha-1.4 (8) diene0.03
(0.01)		ND0.02
(0.01)		NDNDND
 Eucalyptol0.40
(0.03)		ND0.47
(0.01)		NDNDND
 β-Terpineole0.03
(0.01)		ND0.06NDNDND
 β-Linalool0.12ND0.15
(0.01)		NDNDND
 Neomenthol‡0.51
(0.02)		ND0.46
(0.02)		NDNDND
 Neoisomenthol‡0.17
(0.01)		ND0.16
(0.02)		NDNDND
 Pulegone0.19
(0.01)		ND0.21
(0.01)		NDNDND
 Carvone0.05
(0.01)		ND0.05NDNDND
 Piperitone0.06ND0.08NDNDND
 Menthyl acetate0.56
(0.04)		ND0.54
(0.04)		NDNDND
 p-Menth-3-one5.90
(0.44)		0.11
(0.02)		5.76
(0.01)		0.08
(0.01)		0.10
(0.01)		0.06
(0.01)
 Isomenthol‡20.31
(1.03)		0.9
(0.03)		21.51
(0.32)		0.78
(0.24)		0.90
(0.08)		0.70
(0.08)
 Menthol‡71.44
(0.70)		98.98
(0.01)		70.12
(0.35)		99.13
(0.25)		99.00
(0.07)		99.24
(0.09)

  • Results are shown as mean (SD) for n=3 samples.

  • Mean (SD).

  • *p<0.05 relative to Menthol 2020.

  • †p<0.01 relative to Menthol 2020.

  • ‡Cooling agent.

  • ND, not detected.