Manufacturers of synthetic nicotine
| Manufacturer name | Starting material | Resulting product | Stereoselective step |
| Next Generation Labs | Ethyl nicotinate | Racemic (50/50) R/S-nicotine | none |
| Contraf-Nicotex-Tobacco | Ethyl nicotinate | S-nicotine | Stereoselective recrystallisation |
| Zanoprima Lifesciences | Myosmine | S-nicotine | Enzymatic stereoselective step |
| NJOY | Racemic (50/50) R/S-nicotine | S-nicotine | Stereoselective recrystallisation |