Adjusted rate of change in point-on-sales and Google queries indicative of shopping interest for JUUL and Puff Bar regulatory, company sales policy and other events during 2019–2021
| Point-of-sales | Shopping interest relative search volume | |||
| JUUL (n=28 cycles) | Puff Bar (n=28 cycles) | JUUL (n=113 weeks) | Puff Bar (n=113 weeks) | |
| B (95% CI) | B (95% CI) | B (95% CI) | B (95% CI) | |
| T2: Trump Administration announced plans to ban flavours; JUUL Labs announced to halt online sales of its sweet and fruity e-cigarette products | −24.93* (−42.67 to –7.20) | 9.68 (−3.01 to 22.38) | −23.77*** (−31.56 to –15.98) | 10.42 (−2.07 to 22.90) |
| T3: FDA published enforcement guidance policy on unauthorised flavoured cartridge-based e-cigarettes; House approved flavour e-cigarette ban bill | −75.39*** (−91.05 to –59.74) | 32.51*** (21.31 to 43.71) | −42.06*** (−46.77 to –37.35) | 50.94*** (43.39 to 58.49) |
| T4: Puff Bar battled counterfeit sales and suspended sale | −70.61*** (−87.01 to –54.21) | 31.96*** (20.22 to 43.69) | −54.46*** (−62.17 to –46.74) | 43.35*** (30.99 to 55.72) |
| T5: Puff Bar back on the market | −87.25** (−129.89 to –44.60) | 40.31* (9.80 to 70.83) | −53.38*** (−59.54 to –47.21) | 32.61*** (22.73 to 42.48) |
| Puff Bar average price per unit | −8.99 (−23.63 to 5.64) | 3.19 (−7.29 to 13.66) | – | – |
| JUUL Kit average price per unit | 2.63** (0.87 to 4.39) | −0.63 (−1.89 to 0.63) | – | – |
| JUUL Refill average price per unit | −74.23 (−184.65 to 36.20) | 43.83 (−35.20 to 122.85) | – | – |
| EVALI cases | −1.91 (−14.63 to 10.82) | −1.64 (−10.75 to 7.47) | −17.65 (−35.78 to 0.49) | −20.48 (−49.55 to 8.58) |
| COVID-19 cases | −0.00 (−0.00 to 0.00) | 0.00 (−0.00 to 0.00) | −0.00* (−0.01 to –0.00) | −0.01*** (−0.01 to –0.00) |
| Intercept | 618.06* (13.03 to 1223.09) | −260.34 (−693.30 to 172.62) | 84.68*** (78.03 to 91.32) | 10.03 (−0.62 to 20.68) |
*P<0.05, **p<0.01, ***p<0.001.
Reference time period: T1 (both JUUL and Puff Bar sold and marketed as tobacco-derived nicotine-containing products).
Seasonality was also controlled for.
EVALI is conceptualised as total EVALI cases per million individuals during each time period of the dataset.
COVID-19 is conceptualised as the total new COVID-19 cases per million individuals during each time period of the dataset.
EVALI, e-cigarette, or vaping, product use associated lung injury.