Summary of product characteristics assessed in this study
| Labelled nicotine* | Nicotine strength* | Pouch wet weight (g)† | Nicotine (mg/pouch)† | Nicotine (mg/g wet weight)‡ | pH§ | Free-base (%)‡ | Warnings minors (M), pregnancy (P) | GHS label | |
| 1 | Nicotine free | – | 0.617 (0.032) | Not detected | – | 9.6 | – | – | – |
| 2 | Nicotine free | – | 0.575 (0.012) | Not detected | – | 8.8 | – | – | – |
| 3 | – | 1/4 | 0.398 (0.003) | 1.79 (0.07) | 4.48 | 8.0 | 49 | M | – |
| 4 | – | 1/4, ‘easy’ | 0.425 (0.016) | 3.47 (0.16) | 8.18 | 8.8 | 86 | M | 07 |
| 5 | – | 1/4, ‘easy’ | 0.696 (0.064) | 3.55 (0.28) | 5.11 | 8.8 | 86 | M | 07 |
| 6 | – | 3/4 | 0.373 (0.004) | 3.85 (0.06) | 10.3 | 8.4 | 71 | M | – |
| 7 | – | 2/4 | 0.579 (0.027) | 3.99 (0.11) | 6.90 | 8.7 | 83 | M | – |
| 8 | 6 mg/pouch | 2/4 | 0.487 (0.017) | 4.53 (0.25) | 9.30 | 8.9 | 89 | M | – |
| 9 | – | 2/4 | 0.508 (0.019) | 4.80 (0.62) | 9.46 | 7.6 | 28 | M | – |
| 10 | 6 mg/pouch | 2/4 | 0.520 (0.012) | 4.83 (0.25) | 9.28 | 8.8 | 86 | M | 07 |
| 11 | – | 3/5, ‘medium’ | 0.872 (0.020) | 5.25 (0.22) | 6.02 | 5.5 | 0.3 | M | – |
| 12 | – | 3/4, ‘strong’ | 0.577 (0.005) | 5.32 (0.44) | 9.22 | 8.7 | 83 | M | – |
| 13 | 6 mg/pouch | 2/4, ‘medium’ | 0.664 (0.024) | 5.42 (0.22) | 8.15 | 9.0 | 91 | M | 07 |
| 14 | 20 mg | 5/5, ‘extra strong’ | 0.305 (0.027) | 5.72 (0.58) | 18.7 | 8.3 | 66 | M, P | 07 |
| 15 | 8 mg/pouch | 4/5 | 0.501 (0.011) | 5.88 (0.25) | 11.7 | 8.7 | 83 | M | 07 |
| 16 | 10 mg/pouch | 3/4, ‘strong’ | 0.487 (0.029) | 6.12 (0.36) | 12.6 | 9.8 | 98 | M | 07 |
| 17 | 20 mg | 5/5, ‘extra strong’ | 0.351 (0.007) | 6.24 (0.07) | 17.8 | 9.1 | 92 | M, P | 07 |
| 18 | – | 5/5, ‘extra strong’ | 0.403 (0.029) | 6.66 (0.50) | 16.5 | 7.7 | 33 | M, P | 07 |
| 19 | 6 mg/pouch | 2/4 | 0.667 (0.005) | 7.09 (0.13) | 10.6 | 8.0 | 49 | M | 07 |
| 20 | – | 1/5 | 0.449 (0.013) | 7.14 (0.14) | 15.9 | 9.0 | 91 | M, P | 06 |
| 21 | – | 3/4 | 0.674 (0.012) | 7.20 (0.13) | 10.7 | 8.7 | 83 | M | – |
| 22 | – | 4/5, ‘strong’ | 0.407 (0.010) | 7.61 (0.17) | 18.7 | 8.5 | 76 | M | 07 |
| 23 | – | 3/4, ‘strong’ | 0.712 (0.030) | 9.17 (0.45) | 12.9 | 8.8 | 86 | – | 07 |
| 24 | – | – | 0.672 (0.060) | 9.48 (0.36) | 14.1 | 10.3 | 99 | M | 07 |
| 25 | – | – | 0.720 (0.018) | 9.48 (0.53) | 13.2 | 9.8 | 98 | M | 07 |
| 26 | 11 mg/pouch | 4/4, ‘x-strong’ | 0.454 (0.012) | 9.85 (0.09) | 21.7 | 8.2 | 61 | M | 07 |
| 27 | 10 mg/pouch | 3/4, ‘strong’ | 0.621 (0.027) | 10.0 (0.6) | 16.1 | 9.2 | 94 | M | 07 |
| 28 | – | 4/4 | 0.681 (0.021) | 10.4 (0.5) | 15.3 | 8.0 | 49 | M, P | – |
| 29 | – | 4/4, ‘x-strong’ | 0.676 (0.006) | 11.2 (0.2) | 16.6 | 8.2 | 61 | – | 07 |
| 30 | 16 mg/g | – | 0.807 (0.019) | 11.5 (0.5) | 14.3 | 9.5 | 97 | M | 07 |
| 31 | – | ‘Extra strong’ | 0.685 (0.010) | 11.7 (0.1) | 17.1 | 9.9 | 99 | M | – |
| 32 | – | 5/6, ‘ultra’ | 0.864 (0.036) | 12.1 (0.5) | 14.0 | 8.2 | 61 | M | 07 |
| 33 | 20 mg/pouch | ‘Power’ | 0.902 (0.009) | 12.7 (0.3) | 14.1 | 10.2 | 99 | M | 07 |
| 34 | – | 5/6, ‘ultra’ | 0.919 (0.047) | 13.0 (0.3) | 14.1 | 9.0 | 91 | M | 07 |
| 35 | – | – | 0.910 (0.062) | 16.0 (1.7) | 17.6 | 10.2 | 99 | – | – |
| 36 | – | 4/4, ‘extreme strong’ | 0.691 (0.004) | 16.8 (1.3) | 24.3 | 8.1 | 55 | M | – |
| 37 | – | – | 0.746 (0.025) | 17.2 (1.9) | 23.1 | 8.0 | 49 | M | 07 |
| 38 | – | ‘Danger strong’ | 0.735 (0.013) | 19.0 (1.1) | 25.8 | 9.9 | 99 | M, P | – |
| 39 | – | 6/6, ‘max’ | 1.246 (0.010) | 20.2 (0.1) | 16.3 | 8.4 | 71 | M | 07 |
| 40 | – | ‘Extreme’ | 0.459 (0.004) | 20.5 (0.9) | 44.7 | 10.0 | 99 | M, P | 06 |
| 41 | – | ‘Hard’ | 0.341 (0.012) | 25.7 (1.3) | 75.5 | 8.7 | 83 | M, P | 06 |
| 42 | – | ‘Hard’ | 0.408 (0.021) | 27.0 (1.7) | 66.1 | 9.9 | 99 | M, P | 06 |
| 43 | 25 mg | – | 0.597 (0.065) | 27.9 (3.6) | 46.9 | 9.7 | 98 | M | – |
| 44 | – | ‘Hard’ | 0.491 (0.043) | 31.2 (1.6) | 63.8 | 9.7 | 98 | M, P | 06 |
| 45 | 50 mg/pouch | ‘Brutal’ | 0.668 (0.028) | 43.4 (4.6) | 64.8 | 10.1 | 99 | M | 06 |
| 46 | 50 mg/pouch | ‘Brutal’ | 1.064 (0.081) | 47.5 (3.7) | 44.7 | 10.5 | 100 | M | 06 |
Warning labels: M: no use by minors; P: no use during pregnancy; GHS06: toxic; GHS07: harmful.
*As labelled by the manufacturer.
†Mean and SD of triplicate analysis.
‡Calculated using mean values.
§Mean of duplicate analysis.
GHS, Globally Harmonized System for Classification and Labelling of Chemicals.