Elsevier

Preventive Medicine

Volume 27, Issue 2, March 1998, Pages 296-303
Preventive Medicine

Regular Article
Transdermal Nicotine Replacement for Hospitalized Patients: A Randomized Clinical Trial,☆☆

https://doi.org/10.1006/pmed.1998.0266Get rights and content

Abstract

Background.This study was undertaken to assess the safety and efficacy of a treatment involving brief counseling and the nicotine patch among hospital in-patients and to identify variables associated with long-term smoking cessation following hospitalization.

Methods.One hundred eighty-five patients were randomly assigned to one of three smoking cessation interventions: (1) A Minimal Care (MC) condition, consisting of a brief physician-delivered motivational message to stop smoking, (2) a Counseling + Active Nicotine Patch (CAP) condition in which patients received the motivational message, a 6-week supply of nicotine patches, and extended bedside and telephone counseling, and (3) a Counseling + Placebo Patch (CPP) condition identical to the CAP condition except the supplied patches contained no nicotine.

Results.At 6-month follow-up, abstinence rates for the three treatments were 4.9, 6.5, and 9.7% for the MC, CPP, and CAP treatments, respectively. These differences were not statistically significant. Patients admitted for respiratory disease were more likely to quit than patients with any other diagnosis. The nicotine patch was well tolerated by hospital inpatients.

Conclusions.The initiation of nicotine patch therapy during hospitalization appears to be safe when used among patients carrying a wide range of diagnoses. Our study provided no evidence of the superiority of nicotine patches versus placebo, but this does not preclude the possibility that future research using larger samples might detect differences between patch groups. Hospital interventions for smoking cessation may be most effective among patients hospitalized for a smoking-related illness such as respiratory disease.

References (32)

  • MC Fiore et al.

    Signal and noise in minimal interventions for smoking cessation

    Tobacco Control

    (1995)
  • Fiore, M, C, Bailey, W, C, Cohen, S, J, Dorfman, S, F, Goldstein, M, G, Gritz, E, R, Smoking cessation, Rockville, MD,...
  • CT Orleans et al.

    Helping hospitalized smokers quit: new directions for treatment and research

    J Consult Clin Psychol

    (1993)
  • Hospital standards—1992

    (1991)
  • CB Taylor et al.

    A nurse-managed smoking cessation program for hospitalized smokers

    Am J Public Health

    (1996)
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    This research was supported by a research grant provided by the Elan Pharmaceutical Research Corporation, Gainsville, Georgia, and Athlone, Ireland.

    ☆☆

    The authors thank the admissions staff at UWHC for their help in identifying and recruiting patients for this trial.

    2

    To whom reprint requests should be addressed at the Center for Tobacco Research and Intervention, 7275 Medical Sciences Center, 1300 University Avenue, Madison, WI 53706.

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