Elsevier

Preventive Medicine

Volume 30, Issue 4, April 2000, Pages 328-338
Preventive Medicine

Regular Article
Erectile Dysfunction and Coronary Risk Factors: Prospective Results from the Massachusetts Male Aging Study,☆☆

https://doi.org/10.1006/pmed.2000.0643Get rights and content

Abstract

Background. Erectile dysfunction (ED), a wide spread and troublesome condition among middle-aged men, is partly vascular in origin. In the Massachusetts Male Aging Study, a random-sample cohort study, we investigated the relationship between baseline risk factors for coronary heart disease and subsequent ED, on the premise that subclinical arterial insufficiency might be manifested as ED.

Methods. Men ages 40–70, selected from state census lists, were interviewed in 1987–1989 and reinterviewed in 1995–1997. Data were collected and blood was drawn in participants' homes. ED was assessed from responses to a privately self-administered questionnaire. Analysis was restricted to 513 men with no ED at baseline and no diabetes, heart disease, or related medications at either time.

Results. Cigarette smoking at baseline almost doubled the likelihood of moderate or complete ED at followup (24% vs 14%, adjusted for age and covariates, P = 0.01). Cigar smoking and passive exposure to cigarette smoke also significantly predicted incident ED, as did overweight (body-mass index ≥ 28 kg/m2) and a composite coronary risk score. Weaker prospective associations were seen for hypertension and dietary intake of cholesterol and unsaturated fat.

Conclusions. Erectile dysfunction and coronary heart disease share some behaviorally modifiable determinants in men who, like our sample, are free of manifest ED or predisposing illness. Open questions include whether modification of coronary risk factors can prevent ED and whether ED may serve as a sentinel event for coronary disease.

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  • Cited by (0)

    Analysis was supported in part by Pfizer Inc. The authors thank Drs. Marilyn Barbour, Richard Durante, Irwin Goldstein, Ann Hume, Chris Longcope, Diana Salvador, and Susan Yurgalevitch among other MMAS coinvestigators, colleagues, and project staff.

    ☆☆

    The Massachusetts Male Aging Study was supported by grants from the National Institute on Aging (AG-04673) and National Institute of Diabetes and Digestive and Kidney Disease (DK - 44995).

    1

    To whom reprint requests should be addressed at New England Research Institutes, 9 Galen Street, Watertown, MA 02472. Fax: (617) 926-8246. E-mail: [email protected].

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