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An updated meta-analysis of nicotine preloading for smoking cessation: investigating mediators of the effect

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Abstract

Rationale

Using nicotine replacement therapy (NRT) whilst smoking, prior to quitting, is called preloading. Two reviews have estimated the effect of preloading on abstinence, but need updating. Neither investigated possible mediators or moderators of the effect, which could have implications for individual treatment plans.

Objectives

To update the nicotine preloading efficacy estimate and test four hypotheses: (1) Efficacy is mediated through reduced smoking reward, (2) efficacy is mediated through increased NRT adherence post-quit, (3) efficacy is mediated through increased confidence, and (4) behavioural support modifies efficacy.

Methods

Randomised controlled trials were included that allocated cigarette smokers attempting to quit to either a preloading or control condition. A Mantel–Haenszel fixed-effect model was used to calculate risk ratios from quit rates at short- and long-term follow-ups. We carried out sub-group analyses and synthesised the data available on possible mediators and moderators qualitatively.

Results

Eight relevant studies were included, with 2,813 participants. The risk ratio (RR) for short-term abstinence was 1.05, 95% confidence intervals (CI) = 0.92, 1.19, and for long-term abstinence 1.16, 95% CI = 0.97, 1.38. There was a marginal benefit of using nicotine patch rather than gum for preloading, significant at short-term follow-up, and no significant benefit of more intensive pre-quit behavioural support.

Conclusions

We found a weak non-significant effect of nicotine preloading on abstinence. None of our mediational hypotheses received strong support, however evidence suggests that efficacy was enhanced by the patch over acute NRT. Future research needs to investigate the mechanisms of preloading by carrying out mediational analysis.

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Acknowledgments

NL's Ph.D. is funded by the Economic and Social Research Council, through the UK Centre for Tobacco Control Studies. The UKCTCS gratefully acknowledge funding from British Heart Foundation, Cancer Research UK, Economic and Social Research Council, Medical Research Council, and the Department of Health, under the auspices of the UK Clinical Research Collaboration. PA is part-funded by the UKCTCS and the National Institute of Health Research.

Conflicts of interest

NL has received hospitality from Pfizer, manufacturers of smoking cessation medication. PA has done consultancy and research on smoking cessation for Pfizer, McNeil, and Celtic Biotechnology.

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Correspondence to Nicola Lindson.

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Lindson, N., Aveyard, P. An updated meta-analysis of nicotine preloading for smoking cessation: investigating mediators of the effect. Psychopharmacology 214, 579–592 (2011). https://doi.org/10.1007/s00213-010-2069-3

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  • DOI: https://doi.org/10.1007/s00213-010-2069-3

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