Genetic models for the natural history of smoking: evidence for a genetic influence on smoking persistence☆
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2015, NeuropharmacologyCitation Excerpt :In other words, approximately 50% of the variance of whether an individual is a smoker can be attributed to genetic factors. Genetic factors influence multiple aspects of tobacco use including initiation (Heath and Martin, 1993), persistence (Heath, 1990; Heath and Martin, 1993), number of cigarettes smoked (Carmelli et al., 1990) and the ability to stop smoking (Carmelli et al., 1992). Similarly, the behavioral and physiological effects of nicotine, the major psychoactive component in tobacco, are influenced by genetic factors in mice (for an excellent review see (Marks, 2013)).
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Data collection was supported by grants from the Australian National Health and Medical Research Council and the Australian Associated Brewers. Data analysis was supported by ADAMHA Grants DA05588, AA07535 and AA07728.
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We thank Dr. John Mathews, Dr. John Gibson, Dr. Rosemary Jardine, and Marilyn Olsen for assistance with data collection.