Elsevier

Brain Research Bulletin

Volume 23, Issue 3, September 1989, Pages 187-192
Brain Research Bulletin

Prenatal exposure to nicotine impairs nervous system development at a dose which does not affect viability or growth

https://doi.org/10.1016/0361-9230(89)90146-9Get rights and content

Abstract

Prenatal exposure to high doses of nicotine (> 6 mg/kg/day) via maternal infusions has been shown to impair nervous system development and to decrease viability and growth. In the current study, we have examined the effects of infusing pregnant rats with 2 mg/kg of nicotine per day from gestational days 4 through 20. At this lower dose, there was neither interference with maternal weight gain nor any increase in resorption rate. Intrauterine and postnatal growth was maintained at normal or supranormal rates in the exposed offspring. Nevertheless, sufficient nicotine penetrated the fetal brain to cause persistent alterations in [3H]nicotine binding sites, abnormalities of cellular development [assessed by measurements of ornithine decarboxylase (ODC) activity and deoxyribonucleic acid (DNA)], and impairment of development of peripheral noradrenergic projections (assessed by kidney norepinephrine levels); in each case, the neural alterations were virtually equivalent to those obtained previously at the higher, growth-suppressant dosage. These findings indicate that growth impairment alone is insufficient to predict the adverse effects of nicotine on development.

References (40)

  • F.J. Seidler et al.

    Development of central control of norepinephrine turnover and release in the rat heart: Responses to tyramine, 2-deoxyglucose and hydralazine

    Neuroscience

    (1981)
  • T.A. Slotkin et al.

    Role of ornithine decarboxylase and the polyamines in nervous system development

    Brain Res. Bull.

    (1986)
  • T.A. Slotkin et al.

    Effects of prenatal nicotine exposure on neuronal development: Selective actions on central and peripheral catecholaminergic pathways

    Brain Res. Bull.

    (1987)
  • T.A. Slotkin et al.

    Adrenergic control of DNA synthesis in developing rat brain regions: Effects of intracistemal administration of isoproterenol

    Brain Res. Bull.

    (1988)
  • P.J. Whitehouse et al.

    Nicotinic acetylcholine binding sites in Alzheimer's disease

    Brain Res.

    (1986)
  • M. Winick et al.

    Quantitative changes in DNA, RNA and protein during prenatal and postnatal growth in the rat

    Dev. Biol.

    (1965)
  • J.M. Bell et al.

    Perinatal dietary supplementation with a commercial soy lecithin preparation: Effects on behavior and brain biochemistry in the developing rat

    Dev. Psychobiol.

    (1985)
  • M.A. Brazier
  • N.R. Butler et al.

    Smoking in pregnancy and subsequent child development

    Br. Med. J.

    (1973)
  • P.R. Dodge et al.

    Nutrition and the developing nervous system

    (1975)
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