Efficacy of acute administration of nicotine gum in relief of cue-provoked cigarette craving

Psychopharmacology (Berl). 2003 Apr;166(4):343-50. doi: 10.1007/s00213-002-1338-1. Epub 2003 Feb 25.

Abstract

Rationale: Acute cravings, often provoked by exposure to smoking cues, appear to be important triggers for smoking relapse. Relief of acute craving may therefore be an important step in preventing relapse.

Objectives: This study was undertaken to assess the effectiveness of nicotine gum in relieving acute craving.

Methods: A multi-center, randomized, placebo-controlled study was conducted with smokers ( n=296) who quit by using either active or inactive gum for 3 days. On their third day of abstinence, smokers participated in a laboratory session in which they were exposed to a provocative smoking cue, chewed active or inactive gum, and then rated their craving at 5-min intervals for 35 min.

Results: Craving initially decreased in both groups. After 15 min, however, the smokers using active nicotine gum experienced significantly greater craving reductions.

Conclusions: These results suggest that nicotine gum can effectively reduce acute craving following exposure to smoking cues.

Publication types

  • Clinical Trial
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Analysis of Variance
  • Chewing Gum*
  • Cues*
  • Female
  • Humans
  • Male
  • Nicotine / administration & dosage
  • Nicotine / therapeutic use*
  • Smoking / psychology*
  • Smoking Cessation / methods*
  • Smoking Cessation / psychology
  • Smoking Prevention*
  • Treatment Outcome

Substances

  • Chewing Gum
  • Nicotine