The tobacco plant has been used in Native American communities in sacred, traditional and cultural ways prior to the arrival of Christopher Columbus. Early immigrants to North America were introduced to tobacco use by Native Americans and the plant was quickly turned into a commercial success in Europe. Native American images have been used for centuries to commercialize a product that once held only spiritual significance to American Indian tribes. This article provides a history of tobacco, from the sacred use by Native Americans, to the commercialism of tobacco in North America. Included is a review of early to current advertisements using Native American images.