The establishment of a university-based network of colleagues with a shared goal of increasing tobacco research and educational opportunities can enrich the learning environment and ultimately contribute to reducing the toll of smoking. Such a network was established at the University of Michigan, and similar approaches can be adopted at other universities, considering a range of funding levels. This article discusses the mission, structure, accomplishments, and future goals of the network, along with lessons learned and recommendations for successful initialization. Specific examples of network activities are provided, along with references to web sites and lectures. This case study will be useful to any university leader seeking to establish a network of tobacco and nicotine researchers on campus.