It has been suggested that lesbians lack mainstream coping resources and are thus at risk for maladaptive coping efforts, which include substance abuse, However, data for thus at risk for maladaptive coping efforts, which include substance abuse. However, data for this population are sparse. Levels of stress, coping styles, rates of problematic substance use and relationships among these variables were examined. Two hundred sixty-three lesbians completed a self-report questionnaire as part of a larger study. Neither high rates of heavy drinking nor drug use were found in this sample. Among those who did drink excessively, it was associated with avoidant coping. Perceived stress and social resources did not differ significantly from the general female population. Levels of stress, social support, and coping style were not predictive of problematic substance use. The most significant predictor of alcohol use was reliance on bars as a primary social setting. Implications of these findings are discussed.