User profiles for "author:Heiko Müller"
Heiko MüllerOFFIS - Institute for Information Technology Verified email at offis.de Cited by 646 |
The E2F transcription factors: key regulators of cell proliferation
H Müller, K Helin - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2000 - Elsevier
Ever since its discovery, the RB-1 gene and the corresponding protein, pRB, have been a
focal point of cancer research. The isolation of E2F transcription factors provided the key to …
focal point of cancer research. The isolation of E2F transcription factors provided the key to …
Large-scale genotyping identifies 41 new loci associated with breast cancer risk
K Michailidou, P Hall, A Gonzalez-Neira… - Nature …, 2013 - nature.com
Breast cancer is the most common cancer among women. Common variants at 27 loci have
been identified as associated with susceptibility to breast cancer, and these account for∼ …
been identified as associated with susceptibility to breast cancer, and these account for∼ …
E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis
H Müller, AP Bracken, R Vernell… - Genes & …, 2001 - genesdev.cshlp.org
The retinoblastoma protein (pRB) and its two relatives, p107 and p130, regulate
development and cell proliferation in part by inhibiting the activity of E2F-regulated …
development and cell proliferation in part by inhibiting the activity of E2F-regulated …
Apaf-1 is a transcriptional target for E2F and p53
MC Moroni, ES Hickman, EL Denchi, G Caprara… - Nature cell …, 2001 - nature.com
Loss of function of the retinoblastoma protein, pRB, leads to lack of differentiation,
hyperproliferation and apoptosis. Inactivation of pRB results in deregulated E2F activity …
hyperproliferation and apoptosis. Inactivation of pRB results in deregulated E2F activity …
Cyclin D1 protein expression and function in human breast cancer
J Bartkova, J Lukas, H Müller, D Lützhøt… - … journal of cancer, 1994 - Wiley Online Library
Cyclin D1 is a cell‐cycle regulator essential for G1, phase progression and a candidate
proto‐oncogene implicated in pathogenesis of several human tumour types, including …
proto‐oncogene implicated in pathogenesis of several human tumour types, including …
[PDF][PDF] Genetic correction of a LRRK2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression
P Reinhardt, B Schmid, LF Burbulla, DC Schöndorf… - Cell stem cell, 2013 - cell.com
Summary The LRRK2 mutation G2019S is the most common genetic cause of Parkinson's
disease (PD). To better understand the link between mutant LRRK2 and PD pathology, we …
disease (PD). To better understand the link between mutant LRRK2 and PD pathology, we …
Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis
A Sabo, TR Kress, M Pelizzola, S De Pretis, MM Gorski… - Nature, 2014 - nature.com
The c-myc proto-oncogene product, Myc, is a transcription factor that binds thousands of
genomic loci. Recent work suggested that rather than up-and downregulating selected …
genomic loci. Recent work suggested that rather than up-and downregulating selected …
Towards a consensus gesture set: A survey of mid-air gestures in HCI for maximized agreement across domains
M Hosseini, T Ihmels, Z Chen, M Koelle… - Proceedings of the …, 2023 - dl.acm.org
Mid-air gesture-based systems are becoming ubiquitous. Many mid-air gestures control
different kinds of interactive devices, applications, and systems. They are, however, still …
different kinds of interactive devices, applications, and systems. They are, however, still …
Genome-wide association studies identify four ER negative–specific breast cancer risk loci
M Garcia-Closas, FJ Couch, S Lindstrom… - Nature …, 2013 - nature.com
Estrogen receptor (ER)-negative tumors represent 20–30% of all breast cancers, with a
higher proportion occurring in younger women and women of African ancestry. The etiology …
higher proportion occurring in younger women and women of African ancestry. The etiology …
Genome-wide association analysis identifies three new breast cancer susceptibility loci
Breast cancer is the most common cancer among women. To date, 22 common breast
cancer susceptibility loci have been identified accounting for∼ 8% of the heritability of the …
cancer susceptibility loci have been identified accounting for∼ 8% of the heritability of the …