User profiles for "author:Heiko Müller"

Heiko Müller

OFFIS - Institute for Information Technology
Verified email at offis.de
Cited by 646

The E2F transcription factors: key regulators of cell proliferation

H Müller, K Helin - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2000 - Elsevier
Ever since its discovery, the RB-1 gene and the corresponding protein, pRB, have been a
focal point of cancer research. The isolation of E2F transcription factors provided the key to …

Large-scale genotyping identifies 41 new loci associated with breast cancer risk

K Michailidou, P Hall, A Gonzalez-Neira… - Nature …, 2013 - nature.com
Breast cancer is the most common cancer among women. Common variants at 27 loci have
been identified as associated with susceptibility to breast cancer, and these account for∼ …

E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis

H Müller, AP Bracken, R Vernell… - Genes & …, 2001 - genesdev.cshlp.org
The retinoblastoma protein (pRB) and its two relatives, p107 and p130, regulate
development and cell proliferation in part by inhibiting the activity of E2F-regulated …

Apaf-1 is a transcriptional target for E2F and p53

MC Moroni, ES Hickman, EL Denchi, G Caprara… - Nature cell …, 2001 - nature.com
Loss of function of the retinoblastoma protein, pRB, leads to lack of differentiation,
hyperproliferation and apoptosis. Inactivation of pRB results in deregulated E2F activity …

Cyclin D1 protein expression and function in human breast cancer

J Bartkova, J Lukas, H Müller, D Lützhøt… - … journal of cancer, 1994 - Wiley Online Library
Cyclin D1 is a cell‐cycle regulator essential for G1, phase progression and a candidate
proto‐oncogene implicated in pathogenesis of several human tumour types, including …

[PDF][PDF] Genetic correction of a LRRK2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression

P Reinhardt, B Schmid, LF Burbulla, DC Schöndorf… - Cell stem cell, 2013 - cell.com
Summary The LRRK2 mutation G2019S is the most common genetic cause of Parkinson's
disease (PD). To better understand the link between mutant LRRK2 and PD pathology, we …

Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis

A Sabo, TR Kress, M Pelizzola, S De Pretis, MM Gorski… - Nature, 2014 - nature.com
The c-myc proto-oncogene product, Myc, is a transcription factor that binds thousands of
genomic loci. Recent work suggested that rather than up-and downregulating selected …

Towards a consensus gesture set: A survey of mid-air gestures in HCI for maximized agreement across domains

M Hosseini, T Ihmels, Z Chen, M Koelle… - Proceedings of the …, 2023 - dl.acm.org
Mid-air gesture-based systems are becoming ubiquitous. Many mid-air gestures control
different kinds of interactive devices, applications, and systems. They are, however, still …

Genome-wide association studies identify four ER negative–specific breast cancer risk loci

M Garcia-Closas, FJ Couch, S Lindstrom… - Nature …, 2013 - nature.com
Estrogen receptor (ER)-negative tumors represent 20–30% of all breast cancers, with a
higher proportion occurring in younger women and women of African ancestry. The etiology …

Genome-wide association analysis identifies three new breast cancer susceptibility loci

M Ghoussaini, O Fletcher, K Michailidou, C Turnbull… - Nature …, 2012 - nature.com
Breast cancer is the most common cancer among women. To date, 22 common breast
cancer susceptibility loci have been identified accounting for∼ 8% of the heritability of the …