Cigarettes are among the most addicting products known, and the vast majority of people
who quit smoking relapse within days. 1, 2 In the United States, less than 10 percent of the …

It is well established that nicotine meets all criteria of a highly addictive drug. However, as
recognized by the US surgeon general, the nicotine delivery system itself is an important …

Examined the effects of nicotine administration and cigarette smoking on human
performance to clarify the role of such effects in controlling smoking. The results of 101 …

Abstract Δ9-Tetrahydrocannabinol (THC), the primary psychoactive constituent of marijuana,
is rapidly transferred from lungs to blood during smoking. Oxidative metabolism of THC …

On February 25, 1994, the Food and Drug Administration (FDA) released a letter to the
Coalition on Smoking or Health announcing its intention to consider regulating cigarettes …

We examined differences between arterial and venous concentrations of nicotine in human
subjects. Shortly after smoking a cigarette, levels of nicotine in arterial plasma were more …

Two versions of a 45-item questionnaire on cocaine craving were administered to 225
cocaine users. The Now version asked about current craving for cocaine, and the General …

Knowledge of the epidemiology of tobacco use and dependence can be used to guide
research initiatives, intervention programs, and policy decisions. Both the reduction in the …

The potential role of nicotine in tobacco dependence was inves-tigated using the strategies
of abuse liability assessment. Eight male volunteer cigarette smokers with histories of drug …

Approximately 50% of long‐term cigarette smokers die prematurely from the adverse effects
of smoking, including on cancer, cardiovascular disease, lung disease, or other illness. This …