A study with low statistical power has a reduced chance of detecting a true effect, but it is
less well appreciated that low power also reduces the likelihood that a statistically significant …

Mendelian randomization (MR) is a term that applies to the use of genetic variation to
address causal questions about how modifiable exposures influence different outcomes …

Functional neuroimaging techniques have transformed our ability to probe the
neurobiological basis of behaviour and are increasingly being applied by the wider …

Improving the reliability and efficiency of scientific research will increase the credibility of the
published scientific literature and accelerate discovery. Here we argue for the adoption of …

Tobacco and alcohol use are leading causes of mortality that influence risk for many
complex diseases and disorders. They are heritable, and etiologically related, behaviors that …

Rationale Delayed reward discounting (DRD) is a behavioral economic index of impulsivity
and numerous studies have examined DRD in relation to addictive behavior. To synthesize …

Context Although differences in clinical characteristics exist between major depressive
disorder (MDD) and bipolar disorder (BD), consistent structural brain abnormalities that …

BACKGROUND: We evaluated the magnitude of the reported associations between
amygdala activation and the serotonin transporter gene linked polymorphic region (5 …

Background Smoking contributes to reasons for hospitalisation, and the period of
hospitalisation may be a good time to provide help with quitting. Objectives To determine the …

Background: Many studies report a positive association between smoking and mental
illness. However, the literature remains mixed regarding the direction of this association. We …