Aggregation of hyperphosphorylated tau is one of the characteristic neuropathological
lesions of Alzheimer's disease and other neurodegenerative disorders. Pharmacological …

Unlike other CDKs, CDK9 does not regulate the cell cycle but promotes RNA synthesis in
genetic programmes for cell growth, differentiation and viral pathogenesis. It is becoming …

Diketopiperazines (DKPs), the smallest cyclic peptides, represent an important class of
biologically active natural products and their research has been fundamental to many …

Objective.—Little is known about the influence of advertising on very young children. We,
therefore, measured product logo recognition by subjects aged 3 to 6 years. Design …

During prion disease, an increase in misfolded prion protein (PrP) generated by prion
replication leads to sustained overactivation of the branch of the unfolded protein response …

CDK2 inhibitors have been proposed as effective anti‐cancer therapeutics. We show here
that CYC202 (R‐roscovitine) is a potent inhibitor of recombinant CDK2/cyclin E kinase …

Activation of the PERK branch of the unfolded protein response (UPR) in response to protein
misfolding within the endoplasmic reticulum (ER) results in the transient repression of …

In a routine screening of our small-molecule compound collection we recently identified 4-
arylazo-3, 5-diamino-1 H-pyrazoles as a novel group of ATP antagonists with moderate …

The integrated stress response (ISR) modulates messenger RNA translation to regulate the
mammalian unfolded protein response (UPR), immunity, and memory formation. A chemical …

Much of the controversy surrounding the advertising of tobacco and alcohol products
concerns the impact on young people. Eye tracking was used to determine how a large …