The potential chemical structure of anti‐SARS‐CoV‐2 RNA‐dependent RNA polymerase

J Lung, YS Lin, YH Yang, YL Chou… - Journal of medical …, 2020 - Wiley Online Library
An outbreak of coronavirus disease 2019 (COVID‐19) occurred in Wuhan and it has rapidly
spread to almost all parts of the world. For coronaviruses, RNA‐dependent RNA polymerase …

Design and methods of the Population Assessment of Tobacco and Health (PATH) Study

A Hyland, BK Ambrose, KP Conway… - Tobacco …, 2017 - tobaccocontrol.bmj.com
Background This paper describes the methods and conceptual framework for Wave 1 of the
Population Assessment of Tobacco and Health (PATH) Study data collection. The National …

[HTML][HTML] Tobacco-product use by adults and youths in the United States in 2013 and 2014

KA Kasza, BK Ambrose, KP Conway… - … England Journal of …, 2017 - Mass Medical Soc
Background Noncigarette tobacco products are evolving rapidly, with increasing popularity
in the United States. Methods We present prevalence estimates for 12 types of tobacco …

[HTML][HTML] Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies

M Traylor, M Farrall, EG Holliday, C Sudlow… - The Lancet …, 2012 - thelancet.com
Background Various genome-wide association studies (GWAS) have been done in
ischaemic stroke, identifying a few loci associated with the disease, but sample sizes have …

[HTML][HTML] The influence of age and sex on genetic associations with adult body size and shape: a large-scale genome-wide interaction study

TW Winkler, AE Justice, M Graff, L Barata… - PLoS …, 2015 - journals.plos.org
Genome-wide association studies (GWAS) have identified more than 100 genetic variants
contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI …

Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke

International Stroke Genetics Consortium (ISGC)… - Nature …, 2012 - nature.com
Genetic factors have been implicated in stroke risk, but few replicated associations have
been reported. We conducted a genome-wide association study (GWAS) for ischemic stroke …

[PDF][PDF] Genome analyses of> 200,000 individuals identify 58 loci for chronic inflammation and highlight pathways that link inflammation and complex disorders

S Ligthart, A Vaez, U Võsa, MG Stathopoulou… - The American Journal of …, 2018 - cell.com
C-reactive protein (CRP) is a sensitive biomarker of chronic low-grade inflammation and is
associated with multiple complex diseases. The genetic determinants of chronic …

Obesity increases risk of ischemic stroke in young adults

AB Mitchell, JW Cole, PF McArdle, YC Cheng, KA Ryan… - Stroke, 2015 - Am Heart Assoc
Background and Purpose—Body mass index has been associated with ischemic stroke in
older populations, but its association with stroke in younger populations is not known. In light …

Common variation in PHACTR1 is associated with susceptibility to cervical artery dissection

S Debette, Y Kamatani, TM Metso, M Kloss… - Nature …, 2015 - nature.com
Cervical artery dissection (CeAD), a mural hematoma in a carotid or vertebral artery, is a
major cause of ischemic stroke in young adults although relatively uncommon in the general …

Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and …

JC Bis, M Kavousi, N Franceschini, A Isaacs… - Nature …, 2011 - nature.com
Carotid intima media thickness (cIMT) and plaque determined by ultrasonography are
established measures of subclinical atherosclerosis that each predicts future cardiovascular …